Solving the Mystery of Cellular Energy Generation

In a recent study from the University of Pennsylvania School of Medicine, researchers reported that a cellular transporter known as SLC25A51 determines the entry of an essential cellular coenzyme, nicotinamide adenine mononucleotide (NAD+), into the power plant of cells, the mitochondria. NAD+ plays a crucial role in cellular metabolism in the mitochondria, where it converts nutrients to chemical energy for the cell.

Study Shows a Novel Function of Enzymes that Play a Key Role In Cellular Aging

High levels of oxidants in the body are shown to be harmful to cells and at times can lead to apoptosis. However, a recent study by researchers from Chalmers University of Technology in Sweden revealed that low levels of oxidants were able to slow down cellular aging.

Parasitic Infection Could Assist Mental Health Treatments 🦠🧠💊

Behavior changes in those infected with T. gondii, which currently infects 2.5 billion people worldwide, could be linked to lowered amounts of norepinephrine, a chemical released in the brain as part of stress response, which also controls neuroinflammation. New research into how this common parasite infection alters human behavior could aid in the development of treatments for neurological disorders.

Identifying a Protein that Protects Against Lyme Disease 🦠🧫🧑‍🔬

Yale researchers have discovered a protein capable of protecting hosts from infection with the tick-borne spirochete that causes Lyme Disease. The findings may help diagnose and treat the most common vector-borne disease in North America.

Human Aging Process Biologically Reversed 🧬👴🏼🧖🏻

The aging process has been biologically reversed by giving humans oxygen therapy in a pressurized chamber. Scientists at Tel Aviv University have shown they could turn back the clock in two key areas of the body believed to be responsible for the frailty and ill-health that comes with aging.

Reviving Memory Deficits and Brain Cell Loss in Diabetic Rats 🐀💊🧠

Neuroscientists discovered nicotinamide mononucleotide (NMN) promoted protection of neurons and memory from diabetes-induced brain degeneration in rats, preserving cognitive function. The findings suggest that NMN may provide therapeutic intervention for brain damage and dysfunction in diabetic patients.

Virus Discovery Could Lead to Gut Microbiome Manipulation 🦠🧪🔬

Scientists from Rutgers University have discovered how a common virus within the gut of humans infects and takes over bacteria cells. The findings could be used to control the composition of the gut microbiome, which is important for human health.

Bursts of Radio Waves ‘Stun’ Nerves, Offering Pain Relief from Arthritis ⚡️💊📡

An experimental new treatment for chronic pain appears to provide substantial relief in patients with advanced degenerative arthritis. Scientists have begun treating chronic pain using electrical currents, produced by powerful radio waves, which ‘stun’ nerves and slow pain signals while in route to the brain.

Molecular Switch Controls Ability to Repair Hearing Loss 🔬🦻🧏

In a mice study at Johns Hopkins Medicine, researcher discovered a molecular switch capable of turning off the animal’s ability to repair damaged cells in the inner ear. The findings shed new light on regenerative abilities present in many species of birds and fish, but get turned off in mammals, including humans.

Identifying the Gene Pathway Responsible for Cellular Aging 🧬🔬👵🏼

A new study enhances the knowledge of mesenchymal stem/stromal cell (MSCs) aging and associated diseases and provides insight into developing pharmacological strategies to reduce or reverse the aging process. The research team from the University of Wisconsin-Madison, relied on cellular reprogramming – a commonly used approach to reverse cell aging – to establish a genetically identical young and old cell model for the study.

Molecule Promotes Muscle Health When Magnetized 💪🧲🏋️‍♀️

A recent study led by researchers from the NUS Institute for Health Innovation and Technology has shown how the protein TRPC1, found in muscles, responds to weak oscillating magnetic fields to promote muscle health. Such response is normally activated during exercise. This responsiveness to magnets could be used to stimulate muscle recovery. The use of pulsed magnetic fields to stimulate the effects of exercising could greatly benefit patients with muscle injury, stroke, and frailty from aging.

Drug Reverses Cognitive Decline Within Days 🧠💊🔄

A new study from the University of California San Francisco has shown a new experimental drug can reverse age-related declines in memory and mental flexibility in mice. The drug, called ISRIB, has already been shown to restore memory functions months after traumatic brain injury, reverse cognitive impairments in Down Syndrome, prevent noise-related hearing loss, fight certain types of cancer, and even enhance cognition in healthy animals.

Brown Fat May Protect Against Numerous Chronic Diseases 🦠🧑‍🔬

Unlike white fat, which stores calories, brown fat burns energy and may hold the key to new obesity treatments and more. A new study from Rockefeller University offers strong evidence that those with detectable brown fat were less likely to suffer cardiac and metabolic conditions ranging from type 2 diabetes to coronary artery disease, which is the leading cause of death in the United States.

NMN May Serve as a Novel Therapeutic Approach Against Obesity 💊🔬📉

A new study from the University of Toyama in Japan demonstrated that enhanced synthesis of nicotinamide adenine dinucleotide (NAD+), a molecule at the core of metabolism, is crucial for the development of mature fat cells, known as adipocytes, from precursors. Discovering compounds capable of regulating the size, number, and function of adipocytes and understanding their behaviors could greatly contribute to obesity prevention and treatment.

Effects of Growth Molecules Exuded by Oral Bacteria Assessed by Researchers 🔬🦷🦠

Researchers at the University of Buffalo have discovered a one sided relationship between a friendly bacteria, Veillonella parvula and an oral pathogen, Porphyromonas gingivalis.

Engineered Cartilage Releases Anti-inflammatory Drug to Take Care of Joint Stress🦵🏽💊🧫

Osteoarthritis is a chronic joint disease for which there are no available drugs to modify it. The disease may ultimately result in the patient requiring a total joint replacement, when the diseased and degraded cartilage and surrounding joint tissues cause so much pain and loss of function that the condition becomes incapacitating. Like the touch sensor on a smartphone, cartilage cells sense when stress is being applied, and the inflammation associated with the excessive stress of arthritis causes cartilage to break down.

Rapamycin Regimens Late in Life Appear to Extend Lifespan in Male Mice, but not Female 💊🐁🧬

Life expectancy differences between males and females point to variations in aging. How these aging related differences tie into responsiveness to compounds that combat aging remains a mystery. Researchers from the Jackson Laboratory found that late-life rapamycin dosage extended mouse lifespan in sex-specific manners.

Bacteria Produces Tissue-Healing Toxins🦠🧫🔬

Researchers reported in the journal Cell Reports that the cells and tissue-damaging toxic cocktail from Staphylococcus aureus have positive effects as well. The bacterial toxin stimulates specific immune cells, which in turn produces specialized messenger substances that reduce inflammation and promote healing of tissue.

A Recipe For Regenerating Bioengineered Hair🧫🧬💇‍♀️

Researchers at the RIKEN Center for Biosystems Dynamics Research in Japan have discovered a recipe for continuous cyclical regeneration of cultured hair follicles from hair follicle stem cells.

Common Antidepressant Could Represent First Disease-Modifying Treatment for Osteoarthritis💊🦴🦵🏽

Research headed by scientists at Penn State College of Medicine has found that the antidepressant paroxetine can stop the progression of osteoarthritis, and regenerate damaged cartilage in the joints of mice.

3D Structure of Eye-Lens Protein 👁 🧪🔬

Researchers from Goethe University found that chemical bonds within the eye-lens protein gamma-B crystallin hold the protein together and are therefore important for the function of the protein within the lens. If the dense packing of the protein cannot be maintained, for example due to hereditary changes in the crystallines, the result is lens opacities, known as cataracts, which are the most common cause of vision loss worldwide.


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