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In present study, a series of pyrazolo[1,5-a]pyrimidine derivatives were synthesized through Knoevenagel condensation reactions and evaluated for their inhibitory activity against acetylcholinesterase (AChE) enzyme. The compounds were synthesized by the condensation of 2-aminopyrazole with various substituted phenyl aldehydes in the presence of NaOH in dry ethanol. Among all the screened compounds, compound 2b (IC50 = 6.1μM), was found to be the most active with good activity when compared to the clinically used drug donepezil (IC50 = 11.9μM). The pKi value of compound 2b was 6.26, which was much more than the value of donepezil (pKi = 2.86). The binding mode of compound 2b was further elucidated in silico by molecular docking and hydrogen bonds analysis. This study has potential for the discovery of novel potent acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease.Course of choroiditis in acute and subacute angle-closure glaucoma.
To determine the course of choroidal inflammation in acute and subacute primary angle-closure glaucoma (PACG), and to correlate that course with the clinical features of angle-closure. A prospective study of 30 consecutive patients with acute and subacute PACG in whom macula-off filtering surgery was performed for a persistent (lasting >4 days) angle-closure attack. Choroidal inflammation was assessed by using laser flare photometry, and the course of choroiditis was determined by serial measurements of intraocular pressure (IOP) and central anterior chamber depth (ACD) and by examination of the fundus
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Another measure that will provide further insight on public mood is the sentiment index of the latest round of Gallup polls, which was released last week. The index is based on the percentage of people who feel “either warm or cool” toward the president.
Gallup finds that, although the overall level of his approval ratings has held steady, Obama’s levels of favorability have risen. Moreover, the increase was strongest among independents and those who did not identify with a political party.
Obama’s favorability rating has actually increased by 9 percentage points among independents.
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